• Antibiotics. ...
• Some blood pressure medicines. ...
• Medicines used for cancer treatment (chemotherapy). ...
• Dyes (contrast media). ...
• Illegal drugs. ...
• Medicines used to treat HIV. ...
• Non-steroidal anti-inflammatory drugs. ...
• Ulcer medicines.

What medications should be avoided with kidney disease?

Which antibiotics damage kidneys?

Aminoglycoside antibiotics are known for causing kidney injury—even at low doses. People with chronic kidney disease, dehydration, or those who have been taking these antibiotics for a long time are at particularly high risk. The most toxic aminoglycoside is neomycin, followed by gentamicin, tobramycin, and amikacin.

Which antibiotics are nephrotoxic?

Fortunately, the nephrotoxicity of each of these drugs appears to be reversible provided their administration is stopped soon enough. Patients with underlying renal disease appear to be particularly sensitive to most of these agents.

Are NSAIDs nephrotoxic drugs?

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease in glomerular filtration rate, increase the risk of NSAID-related nephrotoxicity.

Which antibiotics cause nephrotoxicity and ototoxicity?

The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment.

What is drug induced nephrotoxicity?

Nephrotoxicity can be defined as any renal injury caused directly or indirectly by medications, with acute renal failure, tubulopathies, and glomerulopathies as common clinical presentations.

Are diuretics nephrotoxic?

diuretics are not intrinsically nephrotoxic. Diuretics don't seem to directly cause harm to the kidneys (with the possible exception of triamterene). Diuretics often block various ion channels in the renal tubules. This actually reduces the amount of energy expended by the nephron, thereby decreasing oxygen consumption ...

How do nephrotoxic drugs cause kidney damage?

Nephrotoxic medications can elicit damage to the kidney via various mechanisms, including alteration in its structure and function. When evaluating the primary etiologies in renal injury, the incidence of drug-induced toxicity has accounted for 20% of all-cause incidents.

Which drug is nephrotoxic as well as Ototoxic?

It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity.

Is Remdesivir nephrotoxic?

Based on ARF cases reported in VigiBase, and despite the caveats inherent to COVID-19 circumstances, we detected a statistically significant pharmacovigilance signal of nephrotoxicity associated with remdesivir, deserving a thorough qualitative assessment of all available data.

What medications can lower GFR?

Furthermore, diuretics that work with reduced GFR, such as furosemide or metolazone, are useful agents in the treatment of hypertension and hyperkalemia in CKD. However, it is important to note that volume depletion may make a patient more susceptible to an ACEI- or ARB-induced increase in the serum creatinine level.

Is Toradol nephrotoxic?

All NSAIDs may be nephrotoxic, but ketorolac may be more so than others. A likely mechanism may be prostaglandin inhibition. Symptoms of nephrotoxicity range from isolated hyperkalemia to acute renal failure.

Is acetaminophen nephrotoxic?

Acetaminophen (APAP) is a commonly used analgesic agent that has been associated with acute liver and kidney damage when taken in overdoses. APAP or its nephrotoxic metabolite, para-aminophenol (PAP), may be responsible for the kidney damage.

Are aminoglycosides nephrotoxic?

Aminoglycosides are nephrotoxic because a small but sizable proportion of the administered dose (≈5%) is retained in the epithelial cells lining the S1 and S2 segments of the proximal tubules (135) after glomerular filtration (30).

Is omeprazole nephrotoxic?

INTRODUCTION AND AIMS: Omeprazole is a proton pump inhibitor (PPI) for patients with gastroesophageal reflux and peptic ulcer. It was not considered nephrotoxic, but recent case reports and epidemiological studies suggest a paradigm change.

Can amoxicillin cause nephrotoxicity?

Conclusions: Although renal toxicity may occur with amoxicillin ingestions, it is rare and does not seem to be dose related.

Is ceftriaxone contraindicated in renal failure?

Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways.

Can cipro cause kidney problems?

Nephrotoxicity of ciprofloxacin is often underestimated. In addition to causing acute kidney injury, chronic drug toxicity can in some cases lead to chronic kidney disease and eventually end-stage renal disease.

Does SSRI cause kidney problems?

Increased bleeding risk was reported in association with serotonin-selective reuptake inhibitors (SSRIs),²⁹ which may become problematic in advanced CKD and underlying platelet dysfunction related to uremia.

Is Lasix hard on the kidneys?

Water pills like hydrochlorothiazide and furosemide, used for high blood pressure and edema, can cause dehydration and can also lead to swelling and inflammation of the kidneys.